Can I work in the new location while my h1b visa amendment is in process?

You ask the company's attorney this quesiton. You need second opinion? No problem, but not on .

Agree with my colleague that you need to consult your company attorney regarding this. He is the best person to decide, when you should work. Once transfer application is file and you move to different location, your H-1B status may be at risk, if the transfer application is not approved due to some reason. If approved, you should be ok. But commencing work at new location without USCIS approval in hand, is a risky game.

My colleagues are correct, you should consult your company's attorney. If the transfer is denied, you may have some issues, otherwise it may be okay. Again, check with the company's attorney.