What is the Difference with one or two lodgers in California

If you have more than one lodger, you lose the benefit of the lodger rules for both of your lodgers. They are now tenants and you have to follow the regular landlord/tenant rules regarding evictions. Maybe you can make a deal sort of like a "cash for keys" so you don't have to go through a long and potentially expensive eviction process. Speak to an attorney or check with the local rent rules for the county of San Diego. Good luck.